Cefrin powder for injection
Dexa Medica
Ingredients in every vial
| Cefpirome | 1 g |
Each package contains
Other details
| Flavour | None |
W.H.O. classification
| ATC Level 1 | J – Antiinfectives for systemic use |
| ATC Level 2 | J01 – Antibacterials for Systemic Use |
| ATC Level 3 | J01D – Other Beta-Lactam Antibacterials in ATC |
Warnings
Pregnancy
Lactation
Alcohol
Machinery
Available in
 |
Indonesia |
Dosage information
0 TO 12 YEARS OLD
Clinical data for children <12 years of age is insufficient. Therefore, cefpirome should not be used for this age group.
18 YEARS OLD AND ABOVE
The following dosages are recommended for moderate to severe infections in patients with normal renal function:
Complicated upper and lower urinary tract infections
– Unit dose: 1 g
– Dosage intervals: 12 hours
– Total daily dose: 2 g
Skin and soft tissue infections
– Unit dose: 1 g
– Dosage intervals: 12 hours
– Total daily dose: 2 g
Lower respiratory tract infections
– Unit dose: 1 to 2 g
– Dosage intervals: 12 hours
– Total daily dose: 2 to 4 g
Bacteremia/septicemia
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g
Infections in neutropenic patients
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g
Severe infections
– Unit dose: 2 g
– Dosage intervals: 12 hours
– Total daily dose: 4 g
For urinary tract and skin and soft tissue infections, the unit dose may be increased to 2 g in very severe cases.
65 YEARS OLD AND ABOVE
No adjustment is required unless renal impairment is present.
PATIENTS WITH IMPAIRED RENAL FUNCTION
Cefpirome is excreted principally by the kidney. The dose must therefore be reduced in patients with impaired renal function to compensate for the slower excretion. The recommended dosages are:
CrCl 20-50 ml/minute:
Initial dose 1 g, maintenance dose 0.5 g twice daily
Initial dose 2 g, maintenance dose 1 g twice daily
CrCl 5-20 ml/minute:
Initial dose 1 g, maintenance dose 0.5 g once daily
Initial dose 2 g, maintenance dose 1 g once daily
CrCl ˂5 ml/minute (in hemodyalysis patients)
Initial dose 1 g, maintenance dose 0.5 g once daily ± 0.25 g immediately after dialysis
Initial dose 2 g, maintenance dose 1 g once daily ± 0.5 g immediately after dialysis
Indication
For infection treatment, whether before the causative organism is known or infections caused by bacterial organisms sensitive to cefpirome.
– Lower respiratory tract infections (bronchopneumonia, lobar pneumonia)
– Complicated upper (pyelonephritis) and lower urinary tract infections
– Skin and soft tissue infections (cellulitis, skin abscess and infected wound)
– Infections in neutropenic patients
– Bacteremia/septicemia
– Severe infections