Dexyclav 500mg tablets

AGE >12 YEARS OR WEIGHT >40 KG
— Mild to moderate infections:
1 caplet 625 mg, 2-3 times daily

— Severe infections, including urinary tract infections and lower respiratory tract infections:
2 caplets 625 mg, 3 times daily

CHILDREN AGE <12 YEARS OR WEIGHT <40 KG
— Otitis media, sinusitis, lower respiratory tract infections and urinary tract infections:
40/10-60/15 mg/kg body weight per day in divided doses every 8 hours

— Skin and soft tissue infections, tonsillitis:
20/5-40/10 mg/kg body weight per day in divided doses every 8 hours

OTHER DETAILS
To minimize potential gastrointestinal intolerance and to optimized the absorption, it is recommended to take amoxicillin-clavulanate combination at the start of a meal. Treatment should not be extended beyond 14 days without review.

PATIENTS WITH RENAL IMPAIRMENT
Adults and children >12 years OR >40 kg body weight
Mild impairment (creatinine clearance >30 ml/minute):
No change in dosage

Moderate impairment (creatinine clearance 10-30 ml/minute):
1 caplet 625 mg every 12 hours

Severe impairment (creatinine clearance ˂10 ml/minute):
1 caplet 625 mg every 24 hours

— Hemodialysis:
1 caplet 625 mg every 24 hours. Patients should receive an additional dose both during and at the end of dialysis.

Children <12 years of age OR weight 30 ml/minute):
No change in dosage

Moderate impairment (creatinine clearance 10-30 ml/minute):
Caplet – 1 caplet 625 mg every 12 hours

Severe impairment (creatinine clearance ˂10 ml/minute):
Caplet – 1 caplet 625 mg every 24 hours

— Hemodialysis:
Caplet – 1 caplet 625 mg every 24 hours
Patients should receive an additional dose both during and at the end of dialysis

– Upper respiratory tract infections such as tonsillitis, sinusitis, otitis media due to Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
– Lower respiratory tract infections such as acute bacterial exacerbations of chronic bronchitis, lobar and bronchopneumonia due to Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis.
– Genito-urinary tract infections such as urethritis, cystitis, pyelonephritis and female genital infections due to Enterobacteriaceae (especially E.coli), Staphylococcus saprophyticus, and Enterococcus species.
– Skin and soft tissue infections caused by Staphylococcus aureus, Streptococcus pyogenes and Bacteroides species.
– Bone and joint infections such as osteomyelitis caused by Staphylococcus aureus, which is prolonged treatment may be needed.
– Other infections such as septic abortion, puerperal sepsis, intra-abdominal sepsis.