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Isorane inhalation vapour

Marketed by Dexa Medica

Product packaging may vary from one country to another.

Ingredients in every vial

Isoflurane 250 ml

Each package contains

1 bottle of 250 ml

Other details

Dosage form:Inhalation vapour; solution
Flavour None

W.H.O. classification

ATC Level 1 N - Nervous system
ATC Level 2 N01 - Anesthetics
ATC Level 3 N01A - Anesthetics; General



NOT RECOMMENDEDThis item is not safe for use during pregnancy.


NOT RECOMMENDEDThis item is not safe for use during lactation.


CONSULT YOUR DOCTORSafety of this item for use with alcohol has not been established. Please consult your doctor.


NOT RECOMMENDEDThis item should not be used while operating heavy machinery.

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Dosage information

As isoflurane has a mild pungency, inhalation should usually be preceded by the use of a short acting barbiturate, or other intravenous induction agent, to prevent coughing. Salivation and coughing may be troublesome in small children induced with isoflurane. Alternatively, isoflurane with oxygen or with an oxygen/nitrous oxide mixture may be administered. It is recommended that the induction with isoflurane be initiated at a concentration of 0.5%. Concentration of 1.5-3.0% usually produce surgical anaesthesia in 7-10 minutes. Blood pressure decreases during induction but this may be compensated by surgical stimulation.

Adequate anaesthesia for surgery may be sustained with an inspired isoflurane concentration of 1.0% to 2.5% in an oxygen/ 70% nitrous oxide mixture. Additional inspired isoflurane (0.5% to 1.0%) will be required with lower nitrous oxide levels, or when isoflurane is given with oxygen alone or with with air/oxygen mixtures. Blood pressure decreases during maintenance anaesthesia in relation to depth of anaesthesia. That is, blood pressure is inversely related to the isoflurane concentration. Provided there are no other complicating factors this is probably due to peripheral vasodilatation. Cardiac rhythm remain stable. Excessive falls in blood pressure may be due to the depth of anaesthesia and in such circumstances can be corrected by reducing the inspired isoflurane concentration.

Induced hypotension can be achieved by artificially ventilating patients with isoflurane 2.5-4.0%. Pre-treatment with clonidine significantly decreases the isoflurane requirement for maintaining induced hypotension.


General inhalation anaesthetic for use in induction and maintenance.