Strictly by intravenous administration after appropriate dilution. The use of intrathecal route is contraindicated.
It is recommended to infuse vinorelbine over 6-10 minutes after dilution in 20-50 ml of 0.9% NaCl Injection (normal saline solution) or 5% dextrose solution. Administration should always be followed with at least 250 ml of an isotonic solution infusion to flush the vein.
• In monotherapy, the usual dose given is 25-30 mg/m2 once weekly.
• In combination chemotherapy the dose may be the same while the frequency of administration reduced, i.e.: day 1 and 5 every 3 weeks or day 1 and 8 every 3 weeks according to treatment protocol. No dose adjustments are required for renal insufficiency. If moderate or severe neurotoxicity develops, vinorelbine should be discontinued. The dosage should be adjusted according to hematologic toxicity or hepatic insufficiency, whichever results the lower dose.